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Sites and Functional Consequence of VDAC-Alkylphenol Anesthetic Interactions
General anesthetics have previously been shown to bind mitochondrial VDAC. Here, using a photoactive analog of the anesthetic propofol, we determined that alkylphenol anesthetics bind to Gly56 and Val184 on rat VDAC1. By reconstituting rat VDAC into planar bilayers, we determined that propofol poten...
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| Veröffentlicht in: | FEBS Lett |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254586/ https://ncbi.nlm.nih.gov/pubmed/25448677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.10.009 |
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