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Quantification of 5-methylcytosine, 5-hydroxymethylcytosine and 5-carboxylcytosine from the blood of cancer patients by an Enzyme-based Immunoassay

BACKGROUND: Genome-wide aberrations of the classic epigenetic modification 5-methylcytosine (5mC), considered the hallmark of gene silencing, has been implicated to play a pivotal role in mediating carcinogenic transformation of healthy cells. Recently, three epigenetic marks derived from enzymatic...

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Pubblicato in:Anal Chim Acta
Autori principali: Chowdhury, Basudev, Cho, Il-Hoon, Hahn, Noah, Irudayaraj, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254572/
https://ncbi.nlm.nih.gov/pubmed/25441900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aca.2014.09.020
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