The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells

The USFDA approved “epigenetic drug”, Decitabine, exerts its effect by hypomethylating DNA, demonstrating the pivotal role aberrant genome-wide DNA methylation patterns play in cancer ontology. Using sensitive technologies in a cellular model of Acute Myeloid Leukemia, we demonstrate that while Deci...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Chowdhury, Basudev, McGovern, Andrew, Cui, Yi, Choudhury, Samrat Roy, Cho, Il-Hoon, Cooper, Bruce, Chevassut, Timothy, Lossie, Amy C., Irudayaraj, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894448/
https://ncbi.nlm.nih.gov/pubmed/25901663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09281
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