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Analysis of Free Drug Fractions by Ultrafast Affinity Extraction: Interactions of Sulfonylurea Drugs with Normal or Glycated Human Serum Albumin

Ultrafast affinity extraction and a multi-dimensional affinity system were developed for measuring free drug fractions at therapeutic levels. This approach was used to compare the free fractions and global affinity constants of several sulfonylurea drugs in the presence of normal human serum albumin...

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Publicat a:J Chromatogr A
Autors principals: Zheng, Xiwei, Matsuda, Ryan, Hage, David S.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254497/
https://ncbi.nlm.nih.gov/pubmed/25456590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2014.10.092
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