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Analysis of Free Drug Fractions by Ultrafast Affinity Extraction: Interactions of Sulfonylurea Drugs with Normal or Glycated Human Serum Albumin
Ultrafast affinity extraction and a multi-dimensional affinity system were developed for measuring free drug fractions at therapeutic levels. This approach was used to compare the free fractions and global affinity constants of several sulfonylurea drugs in the presence of normal human serum albumin...
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| Veröffentlicht in: | J Chromatogr A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254497/ https://ncbi.nlm.nih.gov/pubmed/25456590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2014.10.092 |
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