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The Mechanism of Double-stranded DNA Sensing through the cGAS-STING Pathway
Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyzes the synthesis of a cyclic dinucleotid...
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| Vydáno v: | Cytokine Growth Factor Rev |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254336/ https://ncbi.nlm.nih.gov/pubmed/25007740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cytogfr.2014.06.006 |
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