Peptidomimetics of Arg-Phe-NH(2) as Small Molecule Agonists of MAS-Related Gene C (MrgC) Receptors

A series of Arg-Phe-NH2 peptidomimetics containing an Arg mimetic were synthesized and tested as agonists of human MrgX1, rat MrgC, and mouse MrgC11 receptors. As predicted from the previously established species specificity, these peptidomimetics were found to be devoid of MrgX1 agonist activity. I...

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Publicado en:Bioorg Med Chem
Autores principales: Hin, Niyada, Alt, Jesse, Zimmermann, Sarah C., Delahanty, Greg, Ferraris, Dana V., Rojas, Camilo, Li, Fengxian, Liu, Qin, Dong, Xinzhong, Slusher, Barbara S., Tsukamoto, Takashi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254045/
https://ncbi.nlm.nih.gov/pubmed/25288495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.025
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