Peptidomimetics of Arg-Phe-NH(2) as Small Molecule Agonists of MAS-Related Gene C (MrgC) Receptors

A series of Arg-Phe-NH2 peptidomimetics containing an Arg mimetic were synthesized and tested as agonists of human MrgX1, rat MrgC, and mouse MrgC11 receptors. As predicted from the previously established species specificity, these peptidomimetics were found to be devoid of MrgX1 agonist activity. I...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Hin, Niyada, Alt, Jesse, Zimmermann, Sarah C., Delahanty, Greg, Ferraris, Dana V., Rojas, Camilo, Li, Fengxian, Liu, Qin, Dong, Xinzhong, Slusher, Barbara S., Tsukamoto, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254045/
https://ncbi.nlm.nih.gov/pubmed/25288495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.025
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