Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia

The μ-opioid receptor (MOR) agonist morphine is commonly used for pain management, but it has severe adverse effects and produces analgesic tolerance. Thus, alternative ways of stimulating MOR activity are needed. We found that MrgC11, a sensory neuron-specific G protein-coupled receptor, may form h...

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Bibliographic Details
Published in:Sci Signal
Main Authors: He, Shao-Qiu, Xu, Qian, Tiwari, Vinod, Yang, Fei, Anderson, Michael, Chen, Zhiyong, Grenald, Shaness A., Raja, Srinivasa N., Dong, Xinzhong, Guan, Yun
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328051/
https://ncbi.nlm.nih.gov/pubmed/29921657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao3134
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