DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA

The Mre11–Rad50–Nbs1 (MRN) complex plays important roles in sensing DNA damage, as well as in resecting and tethering DNA ends, and thus participates in double-strand break repair. An earlier structure of Mre11 bound to a short duplex DNA molecule suggested that each Mre11 in a dimer recognizes one...

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Veröffentlicht in:EMBO J
Hauptverfasser: Sung, Sihyun, Li, Fuyang, Park, Young Bong, Kim, Jin Seok, Kim, Ae-Kyoung, Song, Ok-kyu, Kim, Jiae, Che, Jun, Lee, Sang Eun, Cho, Yunje
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253529/
https://ncbi.nlm.nih.gov/pubmed/25107472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488299
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