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DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA
The Mre11–Rad50–Nbs1 (MRN) complex plays important roles in sensing DNA damage, as well as in resecting and tethering DNA ends, and thus participates in double-strand break repair. An earlier structure of Mre11 bound to a short duplex DNA molecule suggested that each Mre11 in a dimer recognizes one...
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| Pubblicato in: | EMBO J |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BlackWell Publishing Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253529/ https://ncbi.nlm.nih.gov/pubmed/25107472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488299 |
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