Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

Mre11 forms the core of the multifunctional Mre11-Rad50-Nbs1 (MRN) complex that detects DNA double-strand breaks (DSBs), activates the ATM checkpoint kinase, and initiates homologous recombination (HR) repair of DSBs. To de?ne the roles of Mre11 in both DNA bridging and nucleolytic processing during...

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Autori principali: Williams, R. Scott, Moncalian, Gabriel, Williams, Jessica S., Yamada, Yoshiki, Limbo, Oliver, Shin, David S., Groocock, Lynda M., Cahill, Dana, Hitomi, Chiharu, Guenther, Grant, Moiani, Davide, Carney, James P., Russell, Paul, Tainer, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681233/
https://ncbi.nlm.nih.gov/pubmed/18854158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.08.017
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