DNA Double Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection and signaling; yet, how its endo- and exonuclease activities regulate DSB repair by non-homologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic. Here we employed stru...

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Hauptverfasser: Shibata, Atsushi, Moiani, Davide, Arvai, Andrew S., Perry, J. Jefferson P., Harding, Shane M., Genois, Marie-Michelle, Maity, Ranjan, van Rossum-Fikkert, Sari, Kertokalio, Aryandi, Romoli, Filippo, Ismail, Amani, Ismalaj, Ermal, Petricci, Elena, Matthew, J Neale, Bristow, Robert G, Masson, Jean-Yves, Wyman, Claire, Jeggo, Penny, Tainer, John A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909494/
https://ncbi.nlm.nih.gov/pubmed/24316220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.11.003
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