SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1

DNA double-strand breaks (DSBs) activate a signaling pathway known as the DNA damage response (DDR) which via protein–protein interactions and post-translational modifications recruit signaling proteins, such as 53BP1, to chromatin flanking the lesion. Depletion of the SET8 methyltransferase prevent...

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Vydáno v:EMBO Rep
Hlavní autoři: Dulev, Stanimir, Tkach, Johnny, Lin, Sichun, Batada, Nizar N
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253490/
https://ncbi.nlm.nih.gov/pubmed/25252681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439434
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