SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1

DNA double-strand breaks (DSBs) activate a signaling pathway known as the DNA damage response (DDR) which via protein–protein interactions and post-translational modifications recruit signaling proteins, such as 53BP1, to chromatin flanking the lesion. Depletion of the SET8 methyltransferase prevent...

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Detalles Bibliográficos
Publicado en:EMBO Rep
Autores principales: Dulev, Stanimir, Tkach, Johnny, Lin, Sichun, Batada, Nizar N
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253490/
https://ncbi.nlm.nih.gov/pubmed/25252681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439434
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