Early Fear Memory Defects Are Associated with Altered Synaptic Plasticity and Molecular Architecture in the TgCRND8 Alzheimer's Disease Mouse Model

Alzheimer's disease (AD) is a complex and slowly progressing dementing disorder that results in neuronal and synaptic loss, deposition in brain of aberrantly folded proteins, and impairment of spatial and episodic memory. Most studies of mouse models of AD have employed analyses of cognitive st...

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Détails bibliographiques
Publié dans:J Comp Neurol
Auteurs principaux: Steele, John W., Brautigam, Hannah, Short, Jennifer A., Sowa, Allison, Shi, Mengxi, Yadav, Aniruddha, Weaver, Christina M., Westaway, David, Fraser, Paul E., St George-Hyslop, Peter H., Gandy, Sam, Hof, Patrick R., Dickstein, Dara L.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251468/
https://ncbi.nlm.nih.gov/pubmed/24415002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23536
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