Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

In this study, we show augmented autophagy in the retinal pigment epithelial cell line ARPE-19 when cultured in the presence of the lipofuscin pigment A2E. A2E alone does not induce RPE cell death, but cell death was induced in the presence of A2E with the autophagy inhibitor 3-methyladenine (3MA),...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Saadat, Khandakar A.S.M., Murakami, Yusuke, Tan, Xue, Nomura, Yoko, Yasukawa, Tsutomu, Okada, Eiichi, Ikeda, Yasuhiro, Yanagi, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250541/
https://ncbi.nlm.nih.gov/pubmed/25473597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.11.003
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