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Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
In this study, we show augmented autophagy in the retinal pigment epithelial cell line ARPE-19 when cultured in the presence of the lipofuscin pigment A2E. A2E alone does not induce RPE cell death, but cell death was induced in the presence of A2E with the autophagy inhibitor 3-methyladenine (3MA),...
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| Veröffentlicht in: | FEBS Open Bio |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4250541/ https://ncbi.nlm.nih.gov/pubmed/25473597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.11.003 |
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