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Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

In this study, we show augmented autophagy in the retinal pigment epithelial cell line ARPE-19 when cultured in the presence of the lipofuscin pigment A2E. A2E alone does not induce RPE cell death, but cell death was induced in the presence of A2E with the autophagy inhibitor 3-methyladenine (3MA),...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:FEBS Open Bio
Hauptverfasser: Saadat, Khandakar A.S.M., Murakami, Yusuke, Tan, Xue, Nomura, Yoko, Yasukawa, Tsutomu, Okada, Eiichi, Ikeda, Yasuhiro, Yanagi, Yasuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250541/
https://ncbi.nlm.nih.gov/pubmed/25473597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.11.003
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