Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

In this study, we show augmented autophagy in the retinal pigment epithelial cell line ARPE-19 when cultured in the presence of the lipofuscin pigment A2E. A2E alone does not induce RPE cell death, but cell death was induced in the presence of A2E with the autophagy inhibitor 3-methyladenine (3MA),...

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Publicado en:FEBS Open Bio
Autores principales: Saadat, Khandakar A.S.M., Murakami, Yusuke, Tan, Xue, Nomura, Yoko, Yasukawa, Tsutomu, Okada, Eiichi, Ikeda, Yasuhiro, Yanagi, Yasuo
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250541/
https://ncbi.nlm.nih.gov/pubmed/25473597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.11.003
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