The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells

Proteins involved in cholesterol trafficking are known to contribute to the pathogenesis of atherosclerosis and Alzheimer's disease. Allelic variants in the cholesterol transporters apolipoprotein E and ATP-binding cassette protein A1 (ABCA1) have recently been associated with susceptibility to...

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Detalles Bibliográficos
Autores principales: Lakkaraju, Aparna, Finnemann, Silvia C., Rodriguez-Boulan, Enrique
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904145/
https://ncbi.nlm.nih.gov/pubmed/17578916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702504104
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