Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 Gene and Its Contribution to Antimalarial Response

Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed t...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Veiga, Maria Isabel, Osório, Nuno S., Ferreira, Pedro Eduardo, Franzén, Oscar, Dahlstrom, Sabina, Lum, J. Koji, Nosten, Francois, Gil, José Pedro
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249497/
https://ncbi.nlm.nih.gov/pubmed/25267670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03337-14
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