Repeat Polymorphisms in the Low-Complexity Regions of Plasmodium falciparum ABC Transporters and Associations with In Vitro Antimalarial Responses

The Plasmodium falciparum genome is rich in regions of low amino acid complexity which evolve with few constraints on size. To explore the extent of diversity in these loci, we sequenced repeat regions in pfmdr1, pfmdr5, pfmdr6, pfmrp2, and the antigenic locus pfmsp8 in laboratory and cultured-adapt...

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Detalhes bibliográficos
Main Authors: Okombo, John, Abdi, Abdirahman I., Kiara, Steven M., Mwai, Leah, Pole, Lewa, Sutherland, Colin J., Nzila, Alexis, Ochola-Oyier, Lynette Isabella
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837885/
https://ncbi.nlm.nih.gov/pubmed/24080667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01465-13
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