The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya

The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms of Pfmspdbl2 for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was as...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ochola-Oyier, Lynette Isabella, Okombo, John, Mwai, Leah, Kiara, Steven M., Pole, Lewa, Tetteh, Kevin K. A., Nzila, Alexis, Marsh, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325780/
https://ncbi.nlm.nih.gov/pubmed/25534732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03522-14
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