In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya

Resistance to the amino alcohol quinine has been associated with polymorphisms in pfnhe, a sodium hydrogen exchanger. We investigated the role of this gene in quinine resistance in vitro in isolates from Kenya. We analyzed pfnhe whole-gene polymorphisms, using capillary sequencing, and pfcrt at codo...

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Detalhes bibliográficos
Main Authors: Okombo, John, Kiara, Steven M., Rono, Josea, Mwai, Leah, Pole, Lewa, Ohuma, Eric, Borrmann, Steffen, Ochola, Lynette Isabella, Nzila, Alexis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916339/
https://ncbi.nlm.nih.gov/pubmed/20516285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00325-10
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