Polymorphism in PfMRP1 (Plasmodium falciparum Multidrug Resistance Protein 1) Amino Acid 1466 Associated with Resistance to Sulfadoxine-Pyrimethamine Treatment

Sulfadoxine-pyrimethamine (SP) remains widely recommended for intermittent preventive treatment against Plasmodium falciparum malaria for pregnant women and infants in Africa. Resistance to SP is increasing and associated primarily with mutations in the P. falciparum dhfr (Pfdhfr) and Pfdhps genes....

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Main Authors: Dahlström, Sabina, Veiga, M. Isabel, Mårtensson, Andreas, Björkman, Anders, Gil, J. Pedro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687199/
https://ncbi.nlm.nih.gov/pubmed/19364873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00091-09
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