Comparative Pharmacodynamics of Posaconazole in Neutropenic Murine Models of Invasive Pulmonary Aspergillosis and Mucormycosis

We used two established neutropenic murine models of pulmonary aspergillosis and mucormycosis to explore the association between the posaconazole area under the concentration-time curve (AUC)-to-MIC ratio (AUC/MIC) and treatment outcome. Posaconazole serum pharmacokinetics were verified in infected...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Lewis, Russell E., Albert, Nathaniel D., Kontoyiannis, Dimitrios P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249415/
https://ncbi.nlm.nih.gov/pubmed/25182639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03569-14
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