Pharmacodynamic Activity of Amphotericin B Deoxycholate Is Associated with Peak Plasma Concentrations in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis

We conducted a dose fractionation study of neutropenic, corticosteroid-immunosuppressed mice to characterize the pharmacodynamic/pharmacokinetic (PK/PD) parameter most closely associated with amphotericin B (AMB) efficacy in the treatment of invasive pulmonary aspergillosis. Pharmacokinetic paramete...

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Detalhes bibliográficos
Main Authors: Wiederhold, Nathan P., Tam, Vincent H., Chi, Jingduan, Prince, Randall A., Kontoyiannis, Dimitrios P., Lewis, Russell E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366892/
https://ncbi.nlm.nih.gov/pubmed/16436698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.469-473.2006
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