Comparative Analysis of Amphotericin B Lipid Complex and Liposomal Amphotericin B Kinetics of Lung Accumulation and Fungal Clearance in a Murine Model of Acute Invasive Pulmonary Aspergillosis

The reformulation of amphotericin B (AMB) into a lipid complex (AMB lipid complex [ABLC]) or liposomal carrier (liposomal AMB [L-AMB]) changes the rate and extent of drug distribution to the lung. The importance of pharmacokinetic differences among the various lipid AMB formulations in the treatment...

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Autori principali: Lewis, Russell E., Liao, Guangling, Hou, Jinggou, Chamilos, Georgios, Prince, Randall A., Kontoyiannis, Dimitrios P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855500/
https://ncbi.nlm.nih.gov/pubmed/17261624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01449-06
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