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Random Mutagenesis of the Multidrug Transporter AcrB from Escherichia coli for Identification of Putative Target Residues of Efflux Pump Inhibitors

Efflux is an important mechanism of bacterial multidrug resistance (MDR), and the inhibition of MDR pumps by efflux pump inhibitors (EPIs) could be a promising strategy to overcome MDR. 1-(1-Naphthylmethyl)-piperazine (NMP) and phenylalanine-arginine-β-naphthylamide (PAβN) are model EPIs with activi...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Schuster, Sabine, Kohler, Samay, Buck, Annika, Dambacher, Christine, König, Armin, Bohnert, Jürgen A., Kern, Winfried V.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249408/
https://ncbi.nlm.nih.gov/pubmed/25182653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03775-14
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