Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway

We previously reported the X-ray structures of wild-type Escherichia coli AcrB, a proton motive force-dependent multidrug efflux pump, and its N109A mutant. These structures presumably reflect the resting state of AcrB, which can bind drugs. After ligand binding, a proton may bind to an acidic resid...

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Hlavní autoři: Su, Chih-Chia, Li, Ming, Gu, Ruoyu, Takatsuka, Yumiko, McDermott, Gerry, Nikaido, Hiroshi, Yu, Edward W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636240/
https://ncbi.nlm.nih.gov/pubmed/17015668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00684-06
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