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Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB

Efflux pumps of the resistance nodulation cell division (RND) transporter family, such as AcrB of Escherichia coli, play an important role in the development of multidrug resistance, but the molecular basis for their substrate promiscuity is not yet completely understood. From a collection of highly...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Schuster, Sabine, Vavra, Martina, Kern, Winfried V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914648/
https://ncbi.nlm.nih.gov/pubmed/27161641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00314-16
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