Random Mutagenesis of the Multidrug Transporter AcrB from Escherichia coli for Identification of Putative Target Residues of Efflux Pump Inhibitors

Efflux is an important mechanism of bacterial multidrug resistance (MDR), and the inhibition of MDR pumps by efflux pump inhibitors (EPIs) could be a promising strategy to overcome MDR. 1-(1-Naphthylmethyl)-piperazine (NMP) and phenylalanine-arginine-β-naphthylamide (PAβN) are model EPIs with activi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Schuster, Sabine, Kohler, Samay, Buck, Annika, Dambacher, Christine, König, Armin, Bohnert, Jürgen A., Kern, Winfried V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249408/
https://ncbi.nlm.nih.gov/pubmed/25182653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03775-14
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