Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats

BACKGROUND: High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis of pulmonary arterial hypertension. In this study, we explored the relationship between HMGB1 and pulmonary hypertensi...

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Bibliografiska uppgifter
I publikationen:Respir Res
Huvudupphovsmän: Yang, Pil-Sung, Kim, Dae-Hoon, Lee, Yong Joon, Lee, Sang-Eun, Kang, Won Jun, Chang, Hyuk-Jae, Shin, Jeon-Soo
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248446/
https://ncbi.nlm.nih.gov/pubmed/25420924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0148-4
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