Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis

Overabundance of extracellular matrix resulting from hyperproliferation of keloid fibroblasts (KFs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. High-mobility group box 1 (HMGB1) plays important roles in the regulation of cellular death. Suppression of HMGB1...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Jeon, Yeo Reum, Roh, Hyun, Jung, Ji Hyuk, Ahn, Hyo Min, Lee, Ju Hee, Yun, Chae-Ok, Lee, Won Jai
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747471/
https://ncbi.nlm.nih.gov/pubmed/31450620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20174134
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