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Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model
BACKGROUND: The 90-kDa heat-shock protein (HSP90) is an abundant cytosolic chaperone and inhibition of HSP90 by 17-allylamino-17-demethoxygeldanamycin (17-AAG) compromises Transforming growth factor (TGF)-β-mediated transcriptional responses by enhancing TGF-β receptor I and II degradation, thus pre...
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| Publicado no: | Plast Reconstr Surg |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4556118/ https://ncbi.nlm.nih.gov/pubmed/26313837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PRS.0000000000001538 |
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