Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats

BACKGROUND: High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis of pulmonary arterial hypertension. In this study, we explored the relationship between HMGB1 and pulmonary hypertensi...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Yang, Pil-Sung, Kim, Dae-Hoon, Lee, Yong Joon, Lee, Sang-Eun, Kang, Won Jun, Chang, Hyuk-Jae, Shin, Jeon-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248446/
https://ncbi.nlm.nih.gov/pubmed/25420924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0148-4
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