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Physiological sodium concentrations enhance the iodide affinity of the Na(+)/I(−) symporter

The Na(+)/I(−) symporter (NIS) mediates active I(−) transport--the first step in thyroid hormonogenesis-- with a 2Na(+):1I(−) stoichiometry. NIS-mediated (131)I(−) treatment of thyroid cancer post-thyroidectomy is the most effective targeted internal radiation cancer treatment available. Here, to un...

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Publicat a:Nat Commun
Autors principals: Nicola, Juan P., Carrasco, Nancy, Amzel, L. Mario
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248369/
https://ncbi.nlm.nih.gov/pubmed/24888603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4948
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