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Physiological sodium concentrations enhance the iodide affinity of the Na(+)/I(−) symporter
The Na(+)/I(−) symporter (NIS) mediates active I(−) transport--the first step in thyroid hormonogenesis-- with a 2Na(+):1I(−) stoichiometry. NIS-mediated (131)I(−) treatment of thyroid cancer post-thyroidectomy is the most effective targeted internal radiation cancer treatment available. Here, to un...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4248369/ https://ncbi.nlm.nih.gov/pubmed/24888603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4948 |
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