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Asn441 plays a key role in folding and function of the Na(+)/I(−) symporter (NIS)
The Na(+)/I(−) symporter (NIS) is a plasma membrane glycoprotein that mediates active I(−) transport in the thyroid, the first step in the biosynthesis of the iodine-containing thyroid hormones T(3) and T(4). Several NIS mutants have been identified as a cause of congenital I(−) transport defect (IT...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3714583/ https://ncbi.nlm.nih.gov/pubmed/23650190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-229138 |
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