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Asn441 plays a key role in folding and function of the Na(+)/I(−) symporter (NIS)

The Na(+)/I(−) symporter (NIS) is a plasma membrane glycoprotein that mediates active I(−) transport in the thyroid, the first step in the biosynthesis of the iodine-containing thyroid hormones T(3) and T(4). Several NIS mutants have been identified as a cause of congenital I(−) transport defect (IT...

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Main Authors: Li, Wenjing, Nicola, Juan Pablo, Amzel, L. Mario, Carrasco, Nancy
Formáid: Artigo
Teanga:Inglês
Foilsithe: Federation of American Societies for Experimental Biology 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714583/
https://ncbi.nlm.nih.gov/pubmed/23650190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-229138
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