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Na(+) coordination at the Na2 site of the Na(+)/I(−) symporter

The sodium/iodide symporter (NIS) mediates active I(−) transport in the thyroid—the first step in thyroid hormone biosynthesis—with a 2 Na(+): 1 I(−) stoichiometry. The two Na(+) binding sites (Na1 and Na2) and the I(−) binding site interact allosterically: when Na(+) binds to a Na(+) site, the affi...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Ferrandino, Giuseppe, Nicola, Juan Pablo, Sánchez, Yuly E., Echeverria, Ignacia, Liu, Yunlong, Amzel, L. Mario, Carrasco, Nancy
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027462/
https://ncbi.nlm.nih.gov/pubmed/27562170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607231113
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