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Na(+) coordination at the Na2 site of the Na(+)/I(−) symporter
The sodium/iodide symporter (NIS) mediates active I(−) transport in the thyroid—the first step in thyroid hormone biosynthesis—with a 2 Na(+): 1 I(−) stoichiometry. The two Na(+) binding sites (Na1 and Na2) and the I(−) binding site interact allosterically: when Na(+) binds to a Na(+) site, the affi...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027462/ https://ncbi.nlm.nih.gov/pubmed/27562170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607231113 |
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