Mechanism of anion selectivity and stoichiometry of the Na(+)/I(-) symporter (NIS)

I(-) uptake in the thyroid, the first step in thyroid hormone biosynthesis, is mediated by the Na(+)/I(-) symporter (NIS) with an electrogenic 2Na(+) : 1I(-) stoichiometry. We have obtained mechanistic information on NIS by characterizing the congenital I(-) transport defect-causing NIS mutant G93R....

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Detalhes bibliográficos
Main Authors: Paroder-Belenitsky, Monika, Maestas, Matthew J., Dohán, Orsolya, Nicola, Juan Pablo, Reyna-Neyra, Andrea, Follenzi, Antonia, Dadachova, Ekaterina, Eskandari, Sepehr, Amzel, L. Mario, Carrasco, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207644/
https://ncbi.nlm.nih.gov/pubmed/22011571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108278108
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