Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

Near-haploid human cell lines are instrumental for genetic screens and genome engineering as gene inactivation is greatly facilitated by the absence of a second gene copy. However, no completely haploid human cell line has been described, hampering the genetic accessibility of a subset of genes. The...

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Publicat a:Genome Res
Autors principals: Essletzbichler, Patrick, Konopka, Tomasz, Santoro, Federica, Chen, Doris, Gapp, Bianca V., Kralovics, Robert, Brummelkamp, Thijn R., Nijman, Sebastian M.B., Bürckstümmer, Tilmann
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
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Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248322/
https://ncbi.nlm.nih.gov/pubmed/25373145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.177220.114
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