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A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness

The relationship between genotype mutations and phenotype variations determines health in the short term and evolution over the long term, and it hinges on the action of mutations on fitness. A fundamental difficulty in determining this action, however, is that it depends on the unique context of ea...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Katsonis, Panagiotis, Lichtarge, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248321/
https://ncbi.nlm.nih.gov/pubmed/25217195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.176214.114
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