Negative Feedback in Genetic Circuits Confers Evolutionary Resilience and Capacitance

Natural selection for specific functions places limits upon the amino acid substitutions a protein can accept. Mechanisms that expand the range of tolerable amino acid substitutions include chaperones that can rescue destabilized proteins and additional, stability enhancing substitutions. Here, we p...

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Bibliografiske detaljer
Main Authors: Marciano, David C., Lua, Rhonald C., Katsonis, Panagiotis, Amin, Shivas R., Herman, Christophe, Lichtarge, Olivier
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103627/
https://ncbi.nlm.nih.gov/pubmed/24910431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.018
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