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Negative Feedback in Genetic Circuits Confers Evolutionary Resilience and Capacitance
Natural selection for specific functions places limits upon the amino acid substitutions a protein can accept. Mechanisms that expand the range of tolerable amino acid substitutions include chaperones that can rescue destabilized proteins and additional, stability enhancing substitutions. Here, we p...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4103627/ https://ncbi.nlm.nih.gov/pubmed/24910431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.018 |
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