Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

Alternative splicing modulates expression of most human genes. The kinetic model of cotranscriptional splicing suggests that slow elongation expands and that fast elongation compresses the “window of opportunity” for recognition of upstream splice sites, thereby increasing or decreasing inclusion of...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Fong, Nova, Kim, Hyunmin, Zhou, Yu, Ji, Xiong, Qiu, Jinsong, Saldi, Tassa, Diener, Katrina, Jones, Ken, Fu, Xiang-Dong, Bentley, David L.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248296/
https://ncbi.nlm.nih.gov/pubmed/25452276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252106.114
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