Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

Alternative splicing modulates expression of most human genes. The kinetic model of cotranscriptional splicing suggests that slow elongation expands and that fast elongation compresses the “window of opportunity” for recognition of upstream splice sites, thereby increasing or decreasing inclusion of...

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Vydáno v:Genes Dev
Hlavní autoři: Fong, Nova, Kim, Hyunmin, Zhou, Yu, Ji, Xiong, Qiu, Jinsong, Saldi, Tassa, Diener, Katrina, Jones, Ken, Fu, Xiang-Dong, Bentley, David L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248296/
https://ncbi.nlm.nih.gov/pubmed/25452276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252106.114
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