DBIRD integrates alternative mRNA splicing with RNA polymerase II transcript elongation

Alternative mRNA splicing is the main reason vast mammalian proteomic complexity can be achieved with a limited number of genes. Splicing is physically and functionally coupled to transcription, and is greatly affected by the rate of transcript elongation(1,2,3). As the nascent pre-mRNA emerges from...

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Autori principali: Close, Pierre, East, Philip, Dirac-Svejstrup, A. Barbara, Hartmann, Holger, Heron, Mark, Maslen, Sarah, Chariot, Alain, Söding, Johannes, Skehel, Mark, Svejstrup, Jesper Q.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378035/
https://ncbi.nlm.nih.gov/pubmed/22446626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10925
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