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Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability

During transcript elongation in vitro, backtracking of RNA polymerase II (RNAPII) is a frequent occurrence that can lead to transcriptional arrest. The polymerase active site can cleave the transcript during such backtracking, allowing transcription to resume. Transcript cleavage is either stimulate...

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Detalles Bibliográficos
Main Authors: Sigurdsson, Stefan, Dirac-Svejstrup, A. Barbara, Svejstrup, Jesper Q.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994637/
https://ncbi.nlm.nih.gov/pubmed/20417599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.02.026
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