Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

Alternative splicing modulates expression of most human genes. The kinetic model of cotranscriptional splicing suggests that slow elongation expands and that fast elongation compresses the “window of opportunity” for recognition of upstream splice sites, thereby increasing or decreasing inclusion of...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Fong, Nova, Kim, Hyunmin, Zhou, Yu, Ji, Xiong, Qiu, Jinsong, Saldi, Tassa, Diener, Katrina, Jones, Ken, Fu, Xiang-Dong, Bentley, David L.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248296/
https://ncbi.nlm.nih.gov/pubmed/25452276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252106.114
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