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Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8
Most E3 ligases use a RING domain to activate a thioester-linked E2~ubiquitin-like protein (UBL) intermediate and promote UBL transfer to a remotely bound target protein. Nonetheless, RING E3 mechanisms matching a specific UBL and acceptor lysine remain elusive, including for RBX1, which mediates NE...
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| Publicat a: | Cell |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4247792/ https://ncbi.nlm.nih.gov/pubmed/24949976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.04.037 |
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