Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes

Little is known about molecular recognition of acetylated N-termini, despite prevalence of this modification among eukaryotic cytosolic proteins. We report that the family of human DCN-like (DCNL) co-E3s, which promote ligation of the ubiquitin-like protein NEDD8 to cullin targets, recognizes acetyl...

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Main Authors: Monda, Julie K., Scott, Daniel C., Miller, Darcie J., Lydeard, John, King, David, Harper, J. Wade, Bennett, Eric J., Schulman, Brenda A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786212/
https://ncbi.nlm.nih.gov/pubmed/23201271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.10.013
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